Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo
نویسندگان
چکیده
منابع مشابه
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متن کاملRab29 activation of the Parkinson's disease‐associated LRRK2 kinase
Parkinson's disease predisposing LRRK2 kinase phosphorylates a group of Rab GTPase proteins including Rab29, within the effector-binding switch II motif. Previous work indicated that Rab29, located within the PARK16 locus mutated in Parkinson's patients, operates in a common pathway with LRRK2. Here, we show that Rab29 recruits LRRK2 to the trans-Golgi network and greatly stimulates its kinase ...
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ژورنال
عنوان ژورنال: Journal of Parkinson's Disease
سال: 2021
ISSN: 1877-7171,1877-718X
DOI: 10.3233/jpd-202172